Dmitri Ossipov is an Associate Professor in Polymer Chemistry since the beginning 2012. He graduated from Samara State University (Russia) in 1992 and received his PhD in Bioorganic Chemistry from the Uppsala University (Sweden) in October 2002. After working as a PostDoc fellow at the Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Sweden, he joined the Polymer Chemistry program at the Department of Materials Chemistry, Uppsala University in 2004, where he worked for 13 years. In year 2018, he joined the Department of Bioscience and Nutrition at Karolinska Institutet, where he is currently working on a project devoted to the development of smart injectable hydrogels for drug delivery. Dr. Ossipov’s research interests are in the area of the development of biofunctional synthetic or semi-synthetic materials designed to interact with cells in vivo for regenerative medicine and chemotherapy. Current focus is on injectables that are formed from hyaluronic acid (HA) and act locally (in-vivo forming bulk hydrogels) or systemically (nanogels, core-shell type nanoparticles) on HA specific cells. Dr. Ossipov published more than 60 pear-reviewed articles, has filed 4 patients and has been a speaker in more than 30 international

Seminar

“From individual biomacromolecules to nanomedicines and tissue mimics – a modular synthetic approach”

Abstract

Extracellular matrix (ECM) of our body is a collection of biomacromolecules (proteins, carbohydrates) that organizes the basic units of life, cells into tissues and organs. In this talk, I will present one of the important polysaccharide biomacromolecule of ECM, hyaluronic acid, that plays many important roles in cell signaling and tissue development including tumorigenesis. My work focuses on smart chemical modifications of hyaluronic acid that enable construction of tumor-specific nano-carriers for therapeutic and imaging agents, as well as to build hydrogel-based biomaterials for tissue regeneration. Studies were focused on the development of hyaluronic acid nanogels that improve the delivery of theranostics to cancer cells. Additionally, bulk injectable hydrogels were developed to carry suitable growth factors and antimicrobial agents to achieve bone and skin regeneration. By harnessing reversible interactions between biomacromolecules and combination with covalent cross-linking, three dimensional printing of soft hydrogels together with cells was achieved thus opening future possibilities for creation of artificial tissue models on a bench and studying new medicines in vitro.